Genyro's Sidewinder Assembles 320 DNA Molecules in Parallel from a Single Oligo Pool

Ahead of their appearance at SynBioBeta 2026, May 4-7th in San Jose, Genyro announces new data demonstrating Sidewinder's parallel construction of 320 DNA molecules from a single oligo pool with a misconnection rate of one in ten million, a tenfold improvement over results published in Nature in January.

Sidewinder, developed in Kaihang Wang's lab at Caltech and exclusively licensed to San Diego-based Genyro, separates the sequence information of the final product from the instructions guiding its assembly. Removable barcodes at 3-Way Junctions direct fragments into the correct order and are then removed. It is the first DNA construction method to do this.

The January 2026 Nature paper demonstrated a misconnection rate of one in one million. New data, to be presented at SynBioBeta May 6th and published on bioRxiv later this month: 320 molecules in parallel from a single oligo pool, misconnection rate one in ten million. The parallel assembly was enabled by PyWinder, a new design algorithm.

"Biology is shifting from a discipline of discovery to one of design, where it becomes an engineerable, predictable, and programmable substrate for innovation" said Dr. Adrian Woolfson, MD, PhD, President and CEO of Genyro.

Professor Wang, co-founder and Chief Scientific Advisor: "Our goal is to enable the efficient de novo synthesis of all DNA products at different scales, from genes to whole genomes."

Genyro was co-founded by Woolfson, Wang, Noah Robinson (CTO, first author on the Nature paper), and Professor Brian Hie.

Woolfson and Wang present May 6th at 8:35 PM: Turning Biology into a Predictive and Programmable Engineering Material. Woolfson signs his book "On the Future of Species" at 5 p.m. same day.